【スタッフ紹介】藤井 敬子

【卒業年】　1995年
【専門領域】
血液内科学，輸血学，造血細胞移植，CAR-T細胞療法
【資格】
認定内科医（日本内科学会），血液専門医（日本血液学会），日本輸血・細胞治療学会認定医（日本輸血・細胞治療学会），細胞治療認定管理師（日本輸血・細胞治療学会），造血細胞移植認定医（日本造血細胞移植学会），臨床検査専門医（日本臨床検査医学会），臨床検査管理医（日本臨床検査医学会）
【所属学会】
日本内科学会，日本血液学会，日本輸血細胞治療学会，日本造血細胞移植学会，日本臨床検査医学会
【略歴】
1985-1988 　 岡山県立岡山芳泉高等学校
1989-1995 　 浜松医科大学医学部医学科（医師免許取得）
1995-1996　　香川労災病院
1996-1997　　岡山大学医学部附属病院
1997-1998　　高知県立中央病院
1998-2003　 岡山大学大学院医歯薬学総合研究科博士課程（博士号取得）
2001-2006　　岡山市立市民病院
2006-2009　　米国（夫の海外留学に同行）
2009-2014　　岡山大学病院輸血部医員
2014-現在　　岡山大学病院検査部助教
【座右の銘】
「日々の臨床の『なぜ』を、よりよい医療につなげる」

【研究テーマ】
末梢血幹細胞採取時の健常人ドナーにおけるクエン酸中毒発現、電解質異常
小児のアフェレーシス
CAR-T細胞療法のための白血球アフェレーシス

【主な業績】
Research Map　最新の論文　業績へのリンク

Fujii K, Kitamura W, Washio K, Ikeuchi K, Shimono J, Murakami H, Otsuka F, Maeda Y, Fujii N
Pediatric autologous peripheral blood stem cell collection without heparin using a highly concentrated sodium citrate anticoagulant: A retrospective comparison with standard ACD-A.
Transfusion. 2026

Kitamura W, Fujii K, Abe M, Ikeuchi K, Washio K, Otuka F, Maeda Y, Fujii N.
Novel leukocytapheresis method using highly concentrated sodium citrate solution for the manufacturing of tisagenlecleucel.
Transfus Apher Sci. 2025

Kitamura W, Fujii K, Abe M, Ikeuchi K, Shimono J, Washio K, Otuka F, Maeda Y, Fujii N.
Novel method for autologous peripheral blood stem cell harvest using highly concentrated sodium citrate solution replacing acid citrate dextrose solution A.
Transfusion. 2025

Kitamura W, Fujii K, Kobayashi H, Abe M, Fukumi T, Ikeuchi K, Otsuka F, Maeda Y, Fujii N. Factors affecting the development of hypokalemia during apheresis in healthy donors.
Transfus Aphere Sci. 2025

Abe M, Fujii K, Mitsuhashi T, Kitamura W, Ikeuchi K, Fukumi T, Washio K, Otsuka F, Maeda Y, Fujii N.
Novel method of leukocytapheresis using a highly concentrated sodium citrate solution alternative to acid citrate dextrose solution A.
Transfusion. 2025

Fukumi T, Fujii K, Kitamura W, Fujii N, Ikeuchi K, Asano N, Yamamoto A, Kobayasi H, Kondo T, Seike K, Fujiwara H, Asada N, Ennishi D, Matsuoka KI, Otsuka F, Maeda Y, Fujii N.
Markedly elevated serum level of presepsin in agranulocytosis with hematologic malignancy: A potential prognostic factor in a single-institution retrospective study after granulocyte transfusion.
Lab Med. 2025

Kitamura W, Fujii K, Tsuge M, Mitsuhashi T, Kobayashi H, Kamoi C, Yamamoto A, Kondo T, Seike K, Fujiwara H, Asada N, Ennishi D, Matsuoka KI, Fujii N, Maeda Y.
A randomized controlled trial of conventional GVHD prophylaxis with or without teprenone for the prevention of severe acute GVHD.
Ann Hematol. 2025

Abe M, Fujii K, Fujii N, Mitsuhashi T, Fukumi T, Sumii Y, Kimura M, Urata T, Kondo T, Otsuka F, Maeda Y.
Oral calcium supplementation versus placebo in mitigating citrate reactions during apheresis: an open-label randomized control trial.
Hematol Trans Cell Ther. 2024

Jo T, Yoshihara K, Ri M, Tsukada N, Miura N, Fujii K, Fukushima K, Fujiwara S, Shimura Y, Haraguchi K, Kato K, Satake A, Yoshida A, Suzuki R, Ikemoto J, Iwaki K, Takeda W, Yonetani N, Tanosaki R, Y-Fujiwara M, Kahata K, Nagamura-Inoue T, Yoshihara S, Arai Y.
Low platelet counts and low CD4/CD8 ratios at apheresis increase the risk of CAR-T cell manufacturing failure in myeloma.
Blood Neoplasia. 2025 Feb;2(1)100051-100059.

Kitamura W, Urata T, Fujii K, Fukumi T, Ikeuchi K, Seike K, Fujiwara H, Asada N, Ennishi D, Matsuoka KI, Otsuka F, Maeda Y, Fujii N.
Collection efficiency and safety of large-volume leukapheresis for the manufacturing of tisagenlecleucel.
Transfusion. 2024

Sumii Y, Fujii K, Kondo T, Urata T, Kimura M, Fujiwara H, Asada N, Ennishi D, Nishimori H, Matsuoka K, Otsuka F, Maeda Y, Fujii N.
Evaluating the efficiency and safety of large-volume leukapheresis using the Spectra Optia continuous mononuclear cell collection protocol for peripheral blood stem cell collection from healthy donors: A retrospective study.
Transfusion. 2023

Kondo T, Fujii K, Fujii N, Sumii Y, Urata T, Kimura M, Matsuda M, Ikegawa S, Washio K, Fujiwara H, Asada N, Ennishi D, Nishimori H, Matsuoka K, Otsuka F, Maeda Y.
Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch.
Transfusion. 2023

Jo T, Yoshihara S, Okumura Y, Fujii K, Henzan T, Kahata K, Yamazaki R, Takeda W, Umezawa Y, Fukushima K, Ashida T, Yamada-Fujiwara M, Hanajiri R, Yonetani N, Tada Y, Shimura Y, Nishikii H, Shiba N, Mimura N, Ando J, Sato T, Nakashima Y, Ikemoto J, Iwaki K, Fujiwara S, Ri M,
Nagamura-Inoue T, Tanosaki R, Arai Y. Risk factors for CAR-T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan.
Br J Haematol. 2023

Sumii Y, Fujii N, Fujii K, Kondo T, Urata T, Kimura M, Washio K, Fujiwara H, Asada N, Ennishi D, Nishimori H, Matsuoka KI, Otsuka F, Maeda Y.
Red blood cell depletion in small-volume bone marrow processing using manipulation with third-party red blood cells: A comparison of the performance of the COBE spectra and the spectra Optia systems.
Transfusion. 2022

Kondo T, Fujii N, Fujii K, Sumii Y, Urata T, Kimura M, Matsuda M, Ikegawa S, Washio K, Fujiwara H, Asada N, Ennishi D, Nishimori H, Matsuoka KI, Otsuka F, Maeda Y.
Low hematocrit reduces the efficiency of CD34+ cellection when using the Spectra Optia continuous mononuclear cell collection procedure.
Transfusion. 2022

Ikegawa S, Fujii N, Fujii K, Kimura M, Matsuda M, Kondo T, Fujiwara H, Asada N, Ennishi D, Nishimori H, Matsuoka KI, Maeda Y.
Successful neutrophil engraftment supported by granulocyte transfusion in adult allogeneic transplant patients with peri-transplant active infection.
Transfus Apher Sci. 2022

Fujii K, Fujii N, Kondo T, Mitsuhashi T, Nakamura M, Seike K, Sando Y, Kimura M, Matsuda M, Ikegawa S, Sugiura H, Otsuka F, Maeda Y.
Effectiveness of supplemental oral calcium drink in preventing citrate-related adverse effects in peripheral blood progenitor cell collection.
Transfus Apher Sci. 2021

Fujii K, Ishimaru F, Kozuka T, Matsuo K, Nakase K, Kataoka I, Tabayashi T, Shinagawa K, Ikeda K, Harada M, Tanimoto M.:
Elevation of serum hepatocyte growth factor during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilaization.
Br J Haematol. 2004

Fujii K, Ishimaru F, Nakase K, Tabayashi T, Kozuka T, Naoki K, Miyahara M, Toki H, Kitajima K, Harada M, Tanimoto M.:
Over-expression of short isoforms of Helios in patients with adult-T cell leukemia/ lymphoma.
Br J Haematol. 2003

Fujii K, Aoyama M, Shinagawa K, Matsuo K, Takenaka K, Ikeda K, Kojima K, Ishimaru F, Kiura K, Ueoka H, Niiya K, Tanimoto M, Harada M.
Risk of neutropenic fever and early infectious complications after autologous peripheral blood stem cell transplantation for malignant diseases.
Int J Hematol. 2002

【臨床研究】
1）末梢血幹細胞採取における健常人ドナーのクエン酸中毒予防を目指したカルシウム飲料の非盲ランダム化臨床試験（jRCTs061200035）
2）重症急性移植片対宿主病の発症抑制を目的としたテプレノン併用免疫抑制療法の開発（jRCTs061210072）
3）末梢血幹細胞採取における健常人ドナーのクエン酸中毒予防を目指した経口カルシウム剤の非盲検ランダム化臨床試験（jRCTs061220096）
4）高濃度クエン酸ナトリウム溶液を使用した新規成分採血法の非盲検ランダム化比較試験（jRCTs061250017）
【科学研究費補助金等】
＜代表＞
R3.-R5. 科学研究費補助金・基盤研究(C), 急性移植片対宿主病の重篤化抑制を目的としたテプレノン併用免疫抑制療法の開発
R4. 日本輸血・細胞治療学会　臨床研究推進事業, 顆粒球輸血の安全性と効果を評価する前向き観察研究
R7.-R10. 科学研究費補助金・基盤研究(C), 高濃度クエン酸ナトリウム溶液を使用した新規成分採血法のランダム化比較試験