STAFF
Staff
【スタッフ紹介】光延 文裕
【スタッフ紹介】光延 文裕
【卒業年】 1984年（昭和59年）
【学位取得年月】 1988年（昭和63年）3月
【専門領域】
内科学，呼吸器病学，老年医学，アレルギー学
【資格】
総合内科専門医・指導医（日本内科学会），呼吸器専門医・指導医（日本呼吸器学会），老年病専門医・指導医（日本老年医会），アレルギー専門医・指導医（日本アレルギー学会），温泉療法専門医（日本温泉気候物理医学会），産業医（日本医師会）
【所属学会】
日本内科学会，日本呼吸器学会，日本老年医学会，日本アレルギー学会，日本温泉気候物理医学会，日本臨床腫瘍学会，日本リハビリテーション学会，日本リウマチ学会，日本感染症学会，日本放射線影響学会，American Thoracic Society，European Respiratory Society
【略歴】
昭和63年 10月 南カリフォルニア大学研究員
平成 2年 10月 岡山大学医学部附属病院三朝分院助手（岡山大学医学部第２内科入局）
平成 6年 7月 岡山大学医学部附属病院三朝分院講師
平成13年 3月 岡山大学医学部附属病院三朝分院助教授
平成14年 4月 岡山大学大学院医歯学総合研究科長寿社会医学助教授
平成18年 1月 岡山大学医学部附属病院三朝医療センター長
平成19年 4月 岡山大学大学院医歯薬学総合研究科老年医学分野准教授
平成20年 1月 岡山大学病院医学部歯学部附属病院三朝医療センター長事務取扱
平成20年 6月 岡山大学大学院医歯薬学総合研究科老年医学分野教授（現在に至る）
平成20年 6月 岡山大学医学部歯学部附属病院三朝医療センター長
平成21年 4月 岡山大学病院三朝医療センター長（平成28年3月まで）
【一言】
高齢化をはじめとした社会の大きな変化に対応できる柔軟な、かつ医学的エビデンスに基づいた医療の実践を目指しています。
【研究テーマ】
慢性呼吸器疾患、高齢者医療
【主な業績】
1. Etani R, Kataoka T, Kanzaki N, Sakoda A, Tanaka H, Ishimori Y, Mitsunobu F, Taguchi T, Yamaoka K. Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice. J Radiat Res. 2017 May 12:1-12. doi: 10.1093/jrr/rrx021. [Epub ahead of print]
2. Ishimori Y, Tanaka H, Sakoda A, Kataoka T, Yamaoka K, Mitsunobu F. Measurements of radon activity concentration in mouse tissues and organs. Radiat Environ Biophys. 2017 May;56(2):161-165. doi: 10.1007/s00411-017-0682-9. Epub 2017 Jan 25.
3. Etani R, Kataoka T, Kanzaki N, Sakoda A, Tanaka H, Ishimori Y, Mitsunobu F, Yamaoka K. Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice. J Radiat Res. 2016 Jun;57(3):250-7. doi: 10.1093/jrr/rrw014. Epub 2016 Mar 28
4. Kikuchi H, Shiozawa N, Takata S, Ashida K, Mitsunobu F. Effect of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease: a pilot controlled clinical trial. Int J Chron Obstruct Pulmon Dis. 2014;9:9-15. doi: 10.2147/COPD.S50860. Epub 2013 Dec 12.
5. Sakoda A, Ishimori Y, Yamaoka K, Kataoka T, Mitsunobu F. Absorbed doses of lungs from radon retained in airway lumens of mice and rats. Radiat Environ Biophys. 2013; 52(3) August: 389-395. Epub 2013 Jun 15.
6. Nishiyama Y, Kataoka T, Teraoka J, Sakoda A, Tanaka H, Ishimori Y, Mitsunobu F, Taguchi T, Yamaoka K. Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation. Physiol Res. 2013;62(1) February:57-66. Epub 2012 Nov 22.
7. Sakoda A, Ishimor Y, Fukao K, Yamaoka K, Kataoka T, Mitsunobu F. Lung Dosimetry of Inhaled Radon Progeny in Mice. Radiation and Environmental Biophysics., 51(4):425-442, 2012.
8. Kataoka T, Sakoda A, Ishimori Y, Toyota T, Nishiyama Y, Tanaka H, Mitsunobu F, Yamaoka K. Study of the response of superoxide dismutase in mouse organs to radon using a new large-scale facility for exposing small animals to radon. J Radiat Res. 2011;52(6):775-81.
9. Ishimori Y, Mitsunobu F, Yamaoka K, Tanaka H, Kataoka T, Sakoda A. Performance of the first Japanese large-scale facility for radon inhalation experiments with small animals. Radiat Prot Dosimetry. 146(1-3):31-33, Epub 2011.
10. Shiozawa N, Hayashimoto K, Suzuki E, Kikuchi H, Takata S, Ashida K, Watanabe M, Hosaki Y, Mitsunobu F. Lung function and blood markers of nutritional status in non-COPD aging men with smoking history: a cross-sectional study. Int J Chron Obstruct Pulmon Dis. 5:233-40, 2010.
11. Yamaoka K, Mitsunobu F, Kojima S, Shibakura M, Kataoka T, Hanamoto K, Tanizaki Y. The elevation of p53 protein level and SOD activity in the resident blood of the Misasa radon hot spring district. J Radiat Res, 46: 21-24, 2005.
12. Mitsunobu F, Tanizaki Y. The use of computed tomography to assess asthma severity. Curr Opin Allergy Clin Immunol, 5: 85-90, 2005.
13. Yamaoka K, Mitsunobu F, Hanamoto K, Shibuya K, Mori S, Tanizaki Y. Sugita K. Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy. J Radiat Res, 45: 83-88, 2004.
14. Yamaoka K, Mitsunobu F, Hanamoto K, Mori S, Tanizaki Y, Sugita K. Study on biologic effects of radon and thermal therapy on osteoarthritis. J Pain, 5: 20-25, 2004.
15. Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Tanizaki Y, Tanimoto, M. Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma. Clin Exp Allergy, 34: 59-64, 2004.
16. Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Tanizaki, Y. Decreased computed tomographic lung density during exacerbation of asthma. Eur Respir J, 22: 106-112, 2003.
17. Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki, Y. Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma. J Radiat Res, 44: 95-99, 2003.
18. Tsugeno H, Mizuno M, Fujiki S, Okada H, Okamoto M, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y. A proton-pump inhibitor, rabeprazole, improves ventilatory function in patients with asthma associated with gastroesophageal reflux. Scand J Gastroenterol, 38: 456-461, 2003.
19. Mitsunobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida K, Takata S, Yokoi T, Mishima M, Tanizaki, Y. Complexity of terminal airspace geometry assessed by computed tomography in asthma. Am J Respir Crit Care Med, 167: 411-417, 2003.
20. Tsugeno H, Fujita T, Goto, B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori, Y. Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis. Osteoporos Int, 13: 650-656, 2002.
21. Mitsunobu F, Mifune T, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y. Influence of age and disease severity on high resolution CT lung densitometry in asthma. Thorax, 56: 851-856, 2001. Erratum in: Thorax 2002 Feb;57(2):188.
22. Tsugeno H, Goto B, Fujita T, Okamoto M, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tsuji T, Tanizaki Y. Oral glucocorticoid-induced fall in cortical bone volume and density in postmenopausal asthmatic patients. Osteoporos Int, 12: 266-270. 2001.
23. Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Takata S, Tanizaki Y. Enhanced production of leukotrienes by peripheral leukocytes and specific IgE antibodies in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol, 107: 492-498, 2001.
24. Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y, Harada M. Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics. Eur Respir J, 16: 504-508, 2000.
25. Okamoto M, Mitsunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, Harada S, Tanizaki Y, Kataoka M, Niiya K, Harada, M. Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. Int Arch Allergy Immunol, 122: 137-142, 2000.
26. Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Harada S, Tanizaki Y. IgE-mediated and age-related bronchial hyperresponsiveness in patients with asthma. Relationship to family history of the disease. Age Ageing, 29: 215-220, 2000.
27. Tsugeno H, Nakai M, Okamoto M, Harada S, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tanizaki Y, Tsuji, T. Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography. Eur Respir J, 14: 923-927, 1999.
28. Bos TJ, Monteclaro FS, Mitsunobu F, Ball AR Jr, Chang CH, Nishimura T, Vogt PK. Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Genes Dev, 4: 1677-1687, 1990.
29. Mitsunobu F, Fukui M, Oda T, Yamamoto T, Toyoshima K. A mechanism of c-raf-1 activation: fusion of the lipocortin II amino-terminal sequence with the c-raf-1 kinase domain. Oncoge ne, 4: 437-442, 1989.
