【スタッフ紹介】宮原 信明

【卒業年】　1988年

【学位取得年月】　1994年　12月

【専門領域】 呼吸器・アレルギー内科

【資格】
医師免許
医学博士（岡山大学）
日本内科学会認定内科医、専門医、指導医、中国支部評議員
日本呼吸器学会専門医、指導医、代議委員
日本アレルギー学会認定医、指導医、代議委員
日本呼吸器内視鏡学会専門医、指導医、代議委員
 
【研究テーマ】
アレルギー性気道炎症と気道過敏性のメカニズムの解明
気管支喘息およびCOPDの新規治療薬の開発
終末糖化産物受容体（RAGE）の呼吸器疾患との関連
 
【主な業績】

• Miyahara N, et al. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nature Med. 10:865-9, 2004
• Miyahara N, et al. Requirement for the Leukotriene B4 Receptor-1 in Allergen-Induced Airway Hyperresponsiveness. Am J Respir Crit Care Med. 172:161-7, 2005
• Miyahara N, et al. The leukotriene B4 receptor BLT1 is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J Immunol. 176:3157-64, 2006
• Lee YM, Miyahara N, et al. IFN-gamma production during initial infection determines the outcome of re-infection with RSV. Am J Respir Crit Care Med. 177:208-18, 2007
• Miyahara N, et al. Leukotriene B4 receptor-1 BLT1 expression on dendritic cells is required for the development of Th2 responses and allergen-induced airway hyperresponsiveness. J Immunol. 181:1170-8, 2008
• Miyahara S, Miyahara N, et al. Contribution of allergen-specific and non-specific nasal responses to early- and late-ase nasal responses. J Allergy Clin Immunol. 121:718-24, 2008
• Miyahara N, et al. Leukotriene B4 Release from Mast Cells in IgE-Mediated Airway Hyperresponsiveness and Inflammation. Am J Respir Cell Mol Biol. 40:672-82, 2009
• Takeda K, Shiraishi Y, Matsubara S, Miyahara N, et al.. Effects of combination therapy with montelukast and carbocysteine in allergen-induced airway hyperresponsiveness and airway inflammation. Br J Pharmacol. 160:1399-407, 2010
• Waseda K, Miyahara N, et al. Blocking the leukotriene B4 receptor 1 inhibits late ase airway responses in established disease. Am J Respir Cell Mol Biol. 45:851-7, 2011
• Koga H, Miyahara N, et al. Inhibition of neutroil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutroil elastase inhibition attenuates allergic airway responses. Respir Res.14(1):8, 2013
• Ikeda K, Miyahara N, et al. Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema. Am J Respir Cell Mol Biol. 2014;50(1):18-29
• Waseda　K, Miyahara　N, et al. Emphysema requires the receptor for advanced glycation end products triggering on structural cells. Am J Respir Cell Mol Biol i 2015;52(4):482-91

 
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