【スタッフ紹介】宮原信明

【卒業年】1988年（昭和63年）

【学位取得年】1994年（平成6年）

【専門領域】呼吸器内科学、アレルギー内科学、気管支喘息、COPD

【資格】
認定内科医・総合内科専門医（日本内科学会）、呼吸器専門医・指導医（日本呼吸器学会）、アレルギー専門医・指導医（日本アレルギー学会）、気管支鏡専門医・指導医（日本呼吸器内視鏡学会）

【学会での主な役職】
日本呼吸器学会代議員・理事、日本アレルギー学会代議員、日本呼吸器内視鏡学会代議員

【略歴】
1988年（昭和63年）　呉共済病院内科研修医
1991年（平成3年）　岡山大学医学部附属病院第二内科医員
1994年（平成6年）　吉備高原医療リハビリテーションセンター内科副部長
1996年（平成8年）　国立病院機構山口宇部医療センター　呼吸器科医長
2001年（平成13年）　岡山大学病院呼吸器内科　助手
2001年（平成13年）　米国National Jewish Medical and Research Center, Research Associate
2007年（平成19年）　岡山大学病院呼吸器・アレルギー内科　助教
2013年（平成25年）　岡山大学病院呼吸器・アレルギー内科　講師
2015年（平成27年）　岡山大学大学院保健学研究科　検査技術科学分野
生体情報科学領域　教授

【一言】
呼吸器・アレルギー内科領域、検査技術科学領域の診療、研究、教育の発展に貢献できるよう鋭意努力いたします。

【賞】
2015年（平成27年）　American Thoracic Society, abstract award
2009年（平成21年）　ノバルティス研究奨励賞
2007年（平成19年）　American Thoracic Society, travel award
2007年（平成19年）　アボットジャパン・アレルギー学術奨励賞
2007年（平成19年）　武田科学振興財団医学系研究奨励賞受賞
2006年（平成18年）　American Academy of Allergy Asthma and Immunology STAR Program Award

【研究テーマ】
アレルギー性気道炎症と気道過敏性のメカニズムの解明
気管支喘息、COPDおよび間質性肺炎の新規治療薬の開発
終末糖化産物受容体（RAGE）の呼吸器疾患との関連
Neuropeptideの気道炎症における役割

【主な業績】
最近の業績（Pubmedへのリンク）

Oda N, Miyahara N, Taniguchi A, Morichika D, Senoo S, Fujii U, Itano J, Gion Y, Kiura K, Kanehiro A, Maeda Y. Requirement for neuropeptide Y in the development of type-2 responses and allergen-induced airway hyperresponsiveness and inflammation. Am J Physiol Lung Cell Mol Physiol. 2019 in press
Oda N, Miyahara N, Senoo S, Itano J, Taniguchi A, Mirichika D, Fujii U, Maeda Y, Kiura K, Kanehiro A. Severe asthma concomitant with allergic bronchopulmonary aspergillosis successfully treated with mepolizumab. Allergol Int. 2018;67(4):521-523
Higo H, Kurosaki T, Ichihara E, Kubo T, Miyoshi K, Otani S, Sugimoto S, Yamane M, Miyahara N, Kiura K, Miyoshi S, Oto T. Clinical characteristics of Japanese candidates for lung transplant for interstitial lung disease and risk factors for early death while on the waiting list. Respir Investig. 2017;55(4):264-269.
Oda N, Miyahara N, Ichikawa H, Tanimoto Y, Kajimoto K, Sakugawa M, Kawai H, Taniguchi A, Morichika D, Tanimoto M, Kanehiro A, Kiura K. Long-term effects of beta-blocker use on lung function in Japanese patients with chronic obstructive pulmonary disease. Int J COPD. 2017;12:1119-1124
Fujii U, Miyahara N, Taniguchi A, Waseda K, Morichika D, Kurimoto E, Koga H, Kataoka M, Gelfand EW, Cua DJ, Yoshimura A, Tanimoto M, Kanehiro A. IL-23 is essential for the development of elastase-induced pulmonary inflammation and emphysema. Am J Respir Cell Mol Biol 2016;55:697-707
Taniguchi A, Miyahara N, Waseda K, Kurimoto E, Fujii U, Tanimoto Y, 3, Kataoka M, amamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A. Contrasting Roles for the Receptor for Advanced Glycation End-Products on Structural Cells in Allergic Airway Inflammation versus Airway Hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol 309(8):L789-800, 2015
Waseda　K, Miyahara　N, Taniguchi　A, Kurimoto　E, Ikeda　G, Koga　H, Fujii　U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A. Emphysema requires the receptor for advanced glycation end products triggering on structural cells. Am J Respir Cell Mol Biol 52(4):482-91, 2015.
Ikeda K, Miyahara N, Fuchimoto Y, Waseda K, Ono K, Tanimoto Y, Kataoka M, Gelfand EW, Tanimoto M, Kanehiro A. Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema. Am J Respir Cell Mol Biol. 50(1):18-29, 2014.
Kurimoto E, Miyahara N, Kanehiro A, Waseda K, Taniguchi A, Ikeda G, Koga H, Nishimori H, Tanimoto Y, Kataoka M, Iwakura Y, Gelfand EW, Tanimoto M. IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respir Res. 14(1):5 , 2013.
Fuchimoto Y, Kanehiro A, Miyahara N, Koga H, Ikeda G, Waseda K, Tanimoto Y, Ueha S, Kataoka M, Gelfand EW, Tanimoto M. Requirement for CCR5 in the development of allergen-induced airway hyperresponsiveness and inflammation. Am J Respir Cell Mol Biol. 45(6):1248-55, 2011.
Waseda K, Miyahara N, Kanehiro A, Ikeda G, Koga H, Fuchimoto Y, Kurimoto E, Tanimoto Y, Kataoka M, Tanimoto M, Gelfand EW. Blocking the leukotriene B4 receptor 1 inhibits late ase airway responses in established disease. Am J Respir Cell Mol Biol. 45:851-7, 2011.
Miyahara N, Ohnishi H, Miyahara S, Takeda K, Matsubara S, Matsuda H, Okamoto M, Loader JE, Joetham A, Tanimoto M, Dakhama A, Gelfand EW. Leukotriene B4 Release from Mast Cells in IgE-Mediated Airway Hyperresponsiveness and Inflammation. Am J Respir Cell Mol Biol. 40:672-82, 2009.
Miyahara N, Ohnishi H, Matsuda H, Miyahara S, Takeda K, Koya T, Matsubara S, Okamoto M, Dakhama A, Haribabu B, Gelfand EW. Leukotriene B4 receptor-1 (BLT1) expression on dendritic cells is required for the development of Th2 responses and allergen-induced airway hyperresponsiveness. J Immunol. 181:1170-8, 2008.
Ohnishi H, Miyahara N, Dakhama A, Takeda K, Mathis S, Haribabu B, Gelfand EW. Corticosteroids Enhance CD8+ T Cell-Mediated Airway Hyperresponsiveness and Allergic Inflammation by Upregulating Leukotriene B4 Receptor-1. J Allergy Clin Immunol. 121:864-71, 2008.
Miyahara S, Miyahara N, Lucas JJ, Joetham A, Matsubara S, Ohnishi H, Dakhama A, Gelfand EW. Contribution of allergen-specific and non-specific nasal responses to early- and late-ase nasal responses. J Allergy Clin Immunol. 121:718-24, 2008. 　
Lee YM, Miyahara N, Takeda K, Prpich J, Balhorn A, Joetham A, Gelfand EW, Dakhama A. IFN-gamma production during initial infection determines the outcome of re-infection with RSV. Am J Respir Crit Care Med. 177:208-18, 2007.
Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM. Arhgef1 is Required by T Cells for the Development of Airway Hyperreactivity and Inflammation. Am J Respir Crit Care Med. 176:10-9, 2007.
Taube C*, Miyahara N*, Ott V, Swanson B, Takeda K, Loader L, Shultz LD, Tager AM, Luster AD, Dakhama A, Gelfand EW. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. *C.T. and N.M. contributed equally to this work. J Immunol. 176:3157-64, 2006.
Miyahara S, Miyahara N, Matsubara S, Takeda K, Koya T, Gelfand EW. IL-13 is Essential to the Late ase Response in Allergic Rhinitis. J Allergy Clin Immunol. 118:1110-6, 2006.
Miyahara S, Miyahara N, Takeda K, Joetham A, Gelfand EW. Physiological Assessment of Allergic Rhinitis in Mice: Role of the High Affinity IgE Receptor (FcgammaRI). J Allergy Clin Immunol. 116:1020-7, 2005.
Takeda K, Miyahara N, Kodama T, Taube C, Balhorn A, Dakhama A, Kitamura K, HiranoA, Tanimoto M, Gelfand EW. S-carboxymethylcysteine normalises airway responses in sensitized and challenged mice. Eur Respir J. 26:577-85, 2005.
Miyahara N, Takeda K, Miyahara S, Matsubara S, Koya T, Matsubara S, Joetham A, Krishnan E, Dakhama A, Haribabu B, Gelfand EW. Requirement for the Leukotriene B4 Receptor-1 in Allergen-Induced Airway Hyperresponsiveness. Am J Respir Crit Care Med. 172:161-7, 2005.
Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T, Matsubara S, Dakhama A, Tager AM, Luster AD, Gelfand EW. Leukotriene B4 Receptor-1 Is Essential for Allergen-Mediated Recruitment of CD8+ T Cells and Airway Hyperresponsiveness. J Immunol. 174:4979-84, 2005.
Miyahara N, Swanson BJ, Takeda K, Taube C, Miyahara S, Kodama T, Dakhama A, Ott VL, Gelfand EW. Effector CD8(+) T cells mediate inflammation and airway hyper-responsiveness. Nature Med. 10:865-9, 2004.
Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park JW, Miyahara S, Balhorn A, Dakhama A , Gelfand EW. Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. J Immunol. 172:2549-58, 2004.
Takeda K, Miyahara N, Rha YH, Taube C, Yang ES, Joetham A, Kodama T, Balhorn A, Dakhama A, Duez C, Evans AJ, Voelker DR, Gelfand EW. Surfactant Protein D Regulates Airway Function and Allergic Inflammation through Modulation of Macroage Function. Am J Respir Crit Care Med. 168:783-9, 2003.

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【スタッフ紹介】宮原 信明

【スタッフ紹介】宮原信明