【スタッフ紹介】前田 嘉信

【卒業年】 平成4年

【学位取得年月】 平成11年6月

【専門領域】
血液腫瘍学、造血幹細胞移植学

【資格】
日本内科学会認定(認定医・専門医・指導医)
日本血液学会認定(専門医・指導医)
日本造血幹細胞移植学会認定(認定医)

【所属学会】
日本内科学会,日本血液学会,日本造血細胞移植学会,日本免疫学会,日本癌学会、日本臨床腫瘍学会,日本癌治療学会,日本輸血・細胞治療学会,日本リンパ網内系学会,日本感染症学会,アメリカ血液学会

【略歴】
平成 4年 4月 岡山大学医学部第二内科入局
平成 4年 9月 神戸西市民病院内科医師
平成 5年 9月 滝宮総合病院内科医師
平成 6年 9月 国立四国がんセンター内科レジデント
平成 8年 6月 岡山大学医学部附属病院第二内科医員
平成12年10月 愛媛県立中央病院内科医師
平成13年11月 米国 Michigan University, Research fellow
平成16年12月 岡山大学病院 血液・腫瘍内科 助教
平成24年 4月 岡山大学病院 血液・腫瘍内科 講師
平成29年 7月 岡山大学大学院 血液・腫瘍・呼吸器内科学 教授

【一言】
(患者さんへ)世界中で最も進んだ医療を提供したいと考えています
(後進へ)人はなりたい人間になれる

【研究テーマ】
移植免疫、GVHDとGVL

【主な業績】

(2017年7月以降は第二内科の業績を参照)

  1. Asano T, Meguri Y, Yoshioka T, Kishi Y, Iwamoto M, Nakamura M, Sando Y, Yagita H, Koreth J, Kim HT, Alyea EP, Armand P, Cutler CS, Ho VT, Antin JH, Soiffer RJ, Maeda Y, Tanimoto M, Ritz J, Matsuoka KI. PD-1 modulates regulatory T cell homeostasis during low-dose IL-2 therapy. Blood. 2017; 129(15):2186-2197
  2. Kim SJ, Yoon DH, Jaccard A, Chng WJ, Lim ST, Hong H, Park Y, Chang KM, Maeda Y, Ishida F, Shin DY, Kim JS, Jeong SH, Yang DH, Jo JC, Lee GW, Choi CW, Lee WS, Chen TY, Kim K, Jung SH, Murayama T, Oki Y, Advani R, d’Amore F, Schmitz N, Suh C, Suzuki R, Kwong YL, Lin TY, Kim WS. A prognostic index for natural killer cell lymphoma after non-anthracycline- based treatment: a multicentre, retrospective analysis. Lancet Oncol. 2016; 17(3):389-400.
  3. Okamoto S*, Fujiwara H* (*contributed equally), Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Yoshimura A, Tanimoto M, Maeda Y. Anti-IL-12/23 p40 antibody attenuates experimental chronic graft versus host disease via suppression of IFN-γ/IL-17-producing cells. J Immunol. 2015;194(3):1357-63
  4. Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T. α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood. 2015; 125(19):3014-23
  5. Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Chen L, Azuma M, Yagita H, Tanimoto M. Programmed Death-1 Pathway in Host Tissues Ameliorates Th17/Th1-Mediated Experimental Chronic Graft-versus-Host Disease. J Immunol. 2014;193(5):2565-73
  6. Kim SW, Yoon SS, Suzuki R, Matsuno Y, Yi HG, Yoshida T, Imamura M, Wake A, Miura K, Hino M, Ishikawa T, Kim JS, Maeda Y, Lee JJ, Kang HJ,Lee HS, Lee JH, Izutsu K, Fukuda T, Kim CW, Yoshino T, Ohshima K, Nakamura S, Nagafuji K, Suzumiya J, Harada M, Kim CS. Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology. Leukemia. 2013;27(6):1394-7.
  7. Ito Y, Kimura H, Maeda Y, Hashimoto C, Ishida F, Izutsu K, Fukushima N, Isobe Y, Takizawa J, Hasegawa Y, Kobayashi H, Okamura S, Kobayashi H,Yamaguchi M, Suzumiya J, Hyo R, Nakamura S, Kawa K, Oshimi K, Suzuki R. Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type. Clin Cancer Res. 2012;18(15):4183-4190
  8. Nishimori H, Maeda Y, Teshima T, Sugiyama H, Kobayashi K, Yamasuji Y, Kadohisa S, Uryu H, Takeuchi K, Tanaka T, Yoshino T, Iwakura Y, and Tanimoto M. Synthetic Retinoid Am80 Ameliorates Chronic Graft-Versus-Host Disease by Downregulating Th1 and Th17. Blood. 2012; 119(1):285-95
  9. Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R. Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell Tumor Study Group (NKTSG) study. J Clin Oncol. 2011; 29(33):4410-6.
  10. Asakura S, Hashimoto D, Takashima T, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T. Effect of Alloantigen Expression on Non-hematopoietic Cells in Graft-versus-leukemia Effects. J Clin Invest. 2010;120(7):2370-8.
  11. Ennishi D, Maeda Y, Niitsu N, Kojima M, Izutsu K, Takizawa J, Kusumoto S, Okamoto M, Yokoyama M, Takamatsu Y, Sunami K, Miyata A, Murayama K, Sakai A, Matsumoto M, Shinagawa K, Takaki A, Matsuo K, Kinoshita T, Tanimoto M. Hepatic toxicity and prognosis in HCV-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens: a Japanese multicenter analysis. Blood. 2010; 116(24):5119-25.
  12. Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier SG, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello CA, Ferrara JL.Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest. 2008;118: 2562-73.
  13. Maeda Y, Reddy P, Lowler KP, Liu C, Bishop DK, Ferrara JL. Critical role of host gamma delta T cells in experimental acute graft-versus-host disease. Blood. 2005; 106(2): 749-55.
  14. Maeda Y, Levy RB, Reddy P, Liu C, Clouthier SG, Teshima T, Ferrara JL. Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Blood. 2005;105(5):2023-7.
  15. Reddy P*, Maeda Y*, (*contributed equally) Liu C, Krijanovski OI, Korngold R, Ferrara JL. A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses. Nature Med. 2005; 11(11):1244-9.
  16. Min CK, Maeda Y, Lowler K, Liu C, Clouthier S, Lofthus D, Weisiger E, Ferrara JL, Reddy P. Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. Blood. 2004; 104(10):3393-9.
  17. Duffner UA, Maeda Y, Cooke KR, Reddy P, Ordemann R, Liu C, Ferrara JL, Teshima T. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol. 2004 ;172(12):7393-8.
  18. Reddy P, Maeda Y, Hotary K, Liu C, Reznikov LL, Dinarello CA, Ferrara JL. Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proc Natl Acad Sci U S A. 2004;101(11):3921-6.
  19. Ichiba T, Teshima T, Kuick R, Misek DE, Liu C, Takada Y, Maeda Y, Reddy P, Williams DL, Hanash SM, Ferrara JL. Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays. Blood. 2003;102(2):763-71.
  20. Reddy P, Teshima T, Hildebrandt G, Duffner U, Maeda Y, Cooke KR, Ferrara JL. Interleukin 18 preserves a perforin-dependent graft-versus-leukemia effect after allogeneic bone marrow transplantation. Blood. 2002;100(9):3429-31

 

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